Lozakovich now regularly performs with leading orchestras and the world’s eminent conductors including Adam Fischer, Semyon Bychkov, Christoph Eschenbach, Neeme Järvi, Cristian Măcelaru, Kazuki Yamada, Vasily Petrenko, Lahav Shani, Tugan Sokhiev, Dina Slobodeniouk and Lorenzo Viotti. Highlight performances in North America are with the Chicago Symphony Orchestra, Cleveland Symphony Orchestra conducted by Klaus Mäkelä, Pittsburgh Symphony Orchestra and The Philadelphia Orchestra led by Nathalie Stutzmann, Boston Symphony Orchestra under Andris Nelsons and Los Angeles Philharmonic conducted by Esa-Pekka Salonen. A highly sought-after recitalist, Lozakovich performs his recital debut at the Grand Hall of The Concertgebouw this season and next season in Carnegie Hall.

In 1980, he left the USSR and settled in Germany. In 1981, Kremer founded a chamber music festival in Lockenhaus, Austria, with a focus on new and unconventional programming, serving as artistic director for 30 years until 2011. He also made regular appearances at the Verbier Festival until the summer of 2011, when he publicly criticised the perceived 'star culture' aspect of the festival and withdrew from the festival. His partners in performance include Valery Afanassiev, Martha Argerich,[5] Mikhail Pletnev, Oleg Maisenberg, Vadim Sakharov, Mischa Maisky, Yo-Yo Ma, Clemens Hagen, Giedrė Dirvanauskaitė, Yuri Bashmet, Kim Kashkashian, Thomas Zehetmair, Tatiana Grindenko and Per Arne Glorvigen.

In 2020, Hahn and AI roboticist and tech entrepreneur Carol E. Reiley cofounded DeepMusic.ai to work with artists and AI companies to amplify human creativity. Hahn is a noted champion of new works. In 1999 she commissioned Edgar Meyer to write a concerto. She later recorded the piece with the St. Paul Chamber Orchestra.[42] In 2010 a concerto written for Hahn by Jennifer Higdon and recorded with the Royal Liverpool Philharmonic was awarded the Pulitzer Prize in Music. She commissioned 26 contemporary composers to write short encore pieces for In 27 Pieces: the Hilary Hahn Encores. Among the composers are David Del Tredici, Jennifer Higdon, Du Yun, Elliott Sharp, David Lang, Nico Muhly, James Newton Howard, Valentyn Silvestrov, and Max Richter.[44] For the 27th encore she held an open contest that drew more than 400 entries and was won by Jeff Myers. The international premiere tours, from 2011 to 2013, met with wide critical and audience acclaim.[46][47][48] In November 2013 these 27 short pieces were released on Deutsche Grammophon.[49] The recording won the Grammy Award for Best Chamber Music/Small Ensemble Performance. Hahn began her film recording career as the soloist for James Newton Howard's score for M. Night Shyamalan's The Village in 2004. The film was nominated for an Academy Award for Best Original Score.[51] The film uses the piece's second movement to accompany a nine-minute sequence.[52] In 2013, she was the soloist on Andrew Hewitt's score for the film The Sea.[53]